Isa Stürm studied architecture at the ETH Zurich and earned her diploma in 1983 under the direction of Dolf Schnebeli. She was an assistant to Adolf Max Vogt at the chair for the Theory and History of Architecture at the ETHZ. She worked with Santiago Calatrava and Jacques Herzog & Pierre de Meuron before creating an architectural bureau with Urs Wolf in 1988.
Isa Stürm Urs Wolf SA is active in Switzerland and abroad. Among its earliest projects were the Plarenga Domat-Ems garage (1988), the building for the Bureau of Social Security (SVA) of the canton of Zurich (1998), and the housing built on the Röntgenareal (1999). For Expo.02 they developed the Federal Swiss pavilion "Wer bin ich?" ("Who Am I ?" 2002). They also created exhibition architecture for Swiss Design, Akris, the Swiss Art Awards and exhibition stands for industrial and design products. They designed store interiors for Issey Miyake, Yoshi Yamamoto and Kerquelen in New York. Public building projects for culture with landmark status were the Kunst(Zeug)Haus in Rapperswil-Jona (2008) and the “Culture Depot” Lokremise (locomotive depot) in St.Gallen (2010). Other major projects were the Art Museum in Liechtenstein, the Automobile Museum in Teufen, the Nam June Paik Museum in Korea, the Maritime Museum in Aaland, the Martyr’s Square and the Grand Axis in Beirut, Mobile Aids Clinic for Africa, the Presidents' Lobby at the UN in New York, and the Housing Cooperative Waidmatt in Zurich. Current projects include the newly-opened Stadthaus in the industrial district of the City of Zurich and the fashion showrooms in the Bahnhofstrasse. Their buildings and projects have received many awards.
Isa Stürm is actively involved in the theoretical discussion on architecture. She lectures regularly, participates in juries, project evaluations and discussions, and writes essays. She has worked as architectural expert for the Federal Arts Commission and visiting professor for architectural projects at the EPF in Lausanne. Isa Stürm sits on the boards of the Zurich Kunsthalle and the Sitterwerks Foundation in St. Gallen.